Case 9

June 30, 2020

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Patient #9, an 18-year-old female who underwent a kidney transplant in March 2018 which prompted multiple episodes of bacteremia and urosepsis caused by an extended spectrum beta-lactamase (ESBL) producing strain of Escherichia coli. Phage therapy consisting of two different phage products with titers ranging from 1.0 x 10^9 to 1.0 x 10^10 PFU/mL was first […]

Case 8

June 30, 2020

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Patient #8, a 28-year-old female with cystic fibrosis who developed a multidrug resistant Burkholderia dolosa infection in her lungs after having a bilateral lung transplant in early 2018. Despite multiple courses of antibiotics, the patient continued to deteriorate. Phage therapy was initiated in early September and additional doses were supplied in mid-September and early October. The patient’s bacterial […]

Case 7

June 30, 2020

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Patient #7, a 41 year old male who sustained multiple traumas including the left knee. He developed a post-operative wound infection with multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii. A second muscle flap surgery was performed in a final attempt to save the patient’s leg. Following surgery, the patient received a two week course of intravenous bacteriophage therapy. […]

Case 6

June 30, 2020

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Patient #6, a 60 year old male with a left ventricular assist device infected with multidrug resistant Pseudomonas aeruginosa. His blood cultures were positive. He received 6 weeks of an intravenous bacteriophage mixture containing three phage. Phage was provided to the patient in four shipments. Drainage from the device became significantly less, and the patient […]

Case 5

June 30, 2020

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Patient #5, a 25 year old female with cystic fibrosis. She had a long history of multidrug resistant Burkholderia cenocepacia in her sputum. Despite her history, she was able to find a surgeon willing to perform a double lung transplant. Her post-transplant course was complicated by a re-emergence of the multidrug resistant Burkholderia cenocepacia in her […]

Case 4

June 30, 2020

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Patient #4, a 67 year old male with a history of hypersensitivity pneumonitis and pulmonary fibrosis. He underwent bilateral lung transplantation in October 2016. His post-transplant course was complicated, including the development of two episodes of multidrug resistant Pseudomonas aeruginosa pneumonia. Bacteriophage therapy was administered via nebulizer and intravenously, along with adjunctive systemic antibiotics. Therapy […]

Case 3

June 16, 2020

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Patient #3, a 77 year old male, suffered a traumatic brain injury. He developed a craniectomy site infection with multidrug resistant Acinetobacter baumannii. Intravenous bacteriophage therapy was administered for 8 days. The patient initially seemed more alert, but fever and leukocytosis persisted. The craniectomy site and skin flap healed well. Before receipt of the second […]

Case 2

June 16, 2020

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Patient #2, a 2 year old male with a history of DiGeorge Syndrome and complex congenital heart disease. Following cardiac surgery, he developed a recalcitrant multidrug resistant Pseudomonas aeruginosa bacteremia. Bacteriophage therapy was initiated intravenously, but then held due to progressive heart failure. Despite premature cessation of therapy, blood cultures obtained 4 and 5 days […]

Case 1

June 16, 2020

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Patient #1, a 68 year old male, developed a multidrug resistant Acinetobacter baumannii infected pancreatic pseudocyst. Despite multiple antibiotic courses, the patient deteriorated over a four month period and became comatose. Bacteriophage therapy was administered. A marked improvement in the patient’s condition was observed within 48 hours of starting intravenous therapy. Following 11 weeks of therapy, the patient […]