Case 13

June 30, 2020

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Patient #13, a 10-year-old female diagnosed with cystic fibrosis, who was admitted to the hospital for CF exacerbation with an Achromobacter xylosidans infection resistant to all available antibiotics. The patient was initially treated with the experimental antibiotic cefiderocol and 17 days later she began her phage therapy. During the first 5 days of phage therapy, […]

Case 12

June 30, 2020

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Patient #12, a 36-year-old male who, due to a spinal injury, is an incomplete quadriplegic and has an ileal conduit. For over a year, he suffered from recurrent urinary tract infections (RUTI) and bacteremia caused by an extended spectrum beta-lactamase (ESBL) producing strain of Escherichia coli. His phage therapy began February consisted of two different […]

Case 11

June 30, 2020

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Patient #11, a 23-year-old male with cystic fibrosis who developed a multidrug resistant Burkholderia gladioli infection in his chest cavity prior to a lung transplant in 2017. Since the transplant, the patient suffered from a sternal wound infection and recurrent bacteremia caused by the same bacterial pathogen. Phage therapy was initiated in early November 2018. The doctor reported marked clinical […]

Case 10

June 30, 2020

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Patient #10, a 47-year-old male who suffered from significant head trauma after a motor vehicle accident. He was initially treated for a subdural hematoma, but soon after receiving surgery for facial fractures, he developed an abscess and ventriculitis caused by a multidrug resistant strain of Acinetobacter baumannii. The patient was in critical condition with dangerously […]

Case 9

June 30, 2020

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Patient #9, an 18-year-old female who underwent a kidney transplant in March 2018 which prompted multiple episodes of bacteremia and urosepsis caused by an extended spectrum beta-lactamase (ESBL) producing strain of Escherichia coli. Phage therapy consisting of two different phage products with titers ranging from 1.0 x 10^9 to 1.0 x 10^10 PFU/mL was first […]

Case 8

June 30, 2020

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Patient #8, a 28-year-old female with cystic fibrosis who developed a multidrug resistant Burkholderia dolosa infection in her lungs after having a bilateral lung transplant in early 2018. Despite multiple courses of antibiotics, the patient continued to deteriorate. Phage therapy was initiated in early September and additional doses were supplied in mid-September and early October. The patient’s bacterial […]

Case 7

June 30, 2020

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Patient #7, a 41 year old male who sustained multiple traumas including the left knee. He developed a post-operative wound infection with multidrug resistant Klebsiella pneumoniae and Acinetobacter baumannii. A second muscle flap surgery was performed in a final attempt to save the patient’s leg. Following surgery, the patient received a two week course of intravenous bacteriophage therapy. […]

Case 6

June 30, 2020

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Patient #6, a 60 year old male with a left ventricular assist device infected with multidrug resistant Pseudomonas aeruginosa. His blood cultures were positive. He received 6 weeks of an intravenous bacteriophage mixture containing three phage. Phage was provided to the patient in four shipments. Drainage from the device became significantly less, and the patient […]

Case 5

June 30, 2020

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Patient #5, a 25 year old female with cystic fibrosis. She had a long history of multidrug resistant Burkholderia cenocepacia in her sputum. Despite her history, she was able to find a surgeon willing to perform a double lung transplant. Her post-transplant course was complicated by a re-emergence of the multidrug resistant Burkholderia cenocepacia in her […]

Case 4

June 30, 2020

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Patient #4, a 67 year old male with a history of hypersensitivity pneumonitis and pulmonary fibrosis. He underwent bilateral lung transplantation in October 2016. His post-transplant course was complicated, including the development of two episodes of multidrug resistant Pseudomonas aeruginosa pneumonia. Bacteriophage therapy was administered via nebulizer and intravenously, along with adjunctive systemic antibiotics. Therapy […]