Careers

Adaptive Phage Therapeutics (APT) is a clinical-stage biotech company developing innovative bacteriophage therapies addressing the global crisis of antibiotic-resistant bacterial infections. The company is located in Gaithersburg, Maryland and was co-founded by Carl R. Merril, MD an award-winning emeritus NIH scientist. APT’s technology has received significant attention for use in the rescue of patients that had otherwise run out of therapeutic options. Several dramatic case studies have been published and featured in two Netflix documentaries, TIME magazine, MIT Tech Review, and many others. APT is providing patients with compassionate early access to its PhageBank therapy and is advancing phase 1 & 2 clinical trials. The company is also supported by the US Dept of Defense to advance through phase 1 clinical trials an innovative phage-based vaccine for COVID-19.

 

Open positions:

Position Description: Microbiologist I/II – Upstream Production

Exciting opportunity for an experienced microbiologist/phage biologist to join the upstream manufacturing team at Adaptive Phage Therapeutics (APT). In this position, the candidate will work alongside the upstream production team to amplify bacteriophages on host bacterial cultures in mid-scale batches to be used in a clinical setting.

Major responsibilities:

  • Grow bacterial batch culture and amplify bacteriophages in batch cultures including working with single use disposable bioreactor systems.
  • Perform in-process testing of material prior to releasing to downstream manufacturing team(s).
  • Propagate, maintain, and catalogue bacterial cell and bacteriophage lines used for manufacturing of the therapeutic drug product.
  • Perform processes for the manufacture of the therapeutic product(s) under approved Standard Operating Procedures (SOPs).
  • Adhere to the company Quality Management System (QMS) to maintain highly controlled manufacturing processes.
  • Adhere to current Good Manufacturing Practices (cGMP), Good Documentation Practices (GDP), Biological Safety Level-2 (BSL-2), and aseptic technique in all Manufacturing/Laboratory processes.
  • May perform QC testing of the therapeutic product per regulatory guidelines and/or SOPs.
  • May help in the ongoing development of scale up batch culture processes.
  • Must maintain a clean working environment including participation in regular laboratory cleaning schedule per established cleaning SOPs.

Job requirements:

  •  BS in biology or related field.
  • 1 – 2 years of experience in a laboratory setting, prefer experience in microbiology and/or bacteriophage biology.
  • GMP experience preferred.
  • Must be able to lift 40 lbs.
  • Must be able to stand and work for extended periods of time.
  • Will require scheduling flexibility to accommodate varying manufacturing schedules. Weekend shifts are also possible.
  • Outstanding organizational and communication skills.
  • Ability to work independently and as part of a team
  • Self-motivation, adaptability, and a positive attitude

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to [email protected]

Job ID: 2020-004

Position Description: Inventory Specialist

Exciting opportunity for an Inventory Specialist to join the team at Adaptive Phage Therapeutics (APT). The Inventory Specialist will be responsible for the accurate accounting of inventory including receiving, processing, recording, and distributing supplies and materials in the laboratory and manufacturing space. The position will also require the performance of a variety of clerical duties including data entry and maintenance of files and records within a LIMS program.

Major responsibilities:

  • Purchases materials, supplies, and services with daily duties including PO creation and management, executing orders with vendors, receiving materials, and invoice reconciliation with accounts payable.
  • Ensures continued flow of production activities by conducting cycle counts and obtaining delivery of adequate business supplies and raw material for all distribution channels.
  • Resolves complaints and disputes between requestors, vendors, finance, and any other applicable stakeholders.
  • Develops working relationships with suppliers to preserve the company’s good business reputation while still obtaining competitive prices.
  • Follows all quality procedures dictated by APT’s Quality Management System.
  • Complies with applicable antitrust and other purchasing-related laws and regulations including Federal Acquisition Regulations for government contracts.
  • Complies with applicable corporate policies & procedures and FDA/ISO regulations pertaining to the purchasing function.
  • Performs other duties & projects as assigned.

Job requirements:

  • Associates degree or higher in a scientific and/or business field
  • Minimum of 2-years experience in inventory purchasing/management, material coordination, or other related supply chain responsibilities within the life sciences industry
  • Experience with InstantGMP software (or equivalent) preferred
  • Must be able to lift at least 40 pounds
  • Must be able to stand and work for extended periods of time
  • Will require scheduling flexibility to accommodate varying manufacturing schedules
  • Outstanding organizational and communication skills
  • Working knowledge of Microsoft Office programs
  • Ability to work independently and as part of a team
  • Self-motivation, adaptability, and a positive attitude

 

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to [email protected]

Job ID: 2020-002

Position Description:  Bioinformatician

 

Exciting opportunity for experienced Bioinformatician to join the team at Adaptive Phage Therapeutics (APT). The Bioinformatician will manage complex biological data sets, including the complete pipeline for genomic sequence analysis.

Major Responsibilities:

  • Perform computational analysis of various genomic data sets using common bioinformatics tools and pipelines.Tools include but not limited to:
    • SPAdes, CLC Genomics Workbench, RAST, Glimmer, Genemark, PGAP
  • Develop production procedure for analyzing genome data.
  • Register metadata about biomarker data assets in internal systems and databases.
  • Collaborate with scientists and informatics colleagues to inventory, store and catalog available biomarker data for prioritized projects and studies.
  • Communicate extensively with exploratory biomarker data managers, scientists, research associates, operations managers, clinical data managers, analysts, and vendor representatives.
  • Work with data management colleagues to distribute data transfer requests, monitor processing queues and contribute to workflow improvements.
  • Maintain content of internal knowledge sharing and documentation repositories.
  • Management of permissions and access for data stored on internal file systems.
  • Project coordination tasks as a member of the data management team.
  • Coordinate with internal stakeholders and external business partners.
  • Provide reports and recommendations to senior leadership.

Job Requirements:

  • Bachelor’s or Master’s degree in Biology, Life Sciences or a related discipline.
  • Three (3) to Five (5) years experience in computational biology
  • Outstanding communication, collaboration, and problem solving
  • Administrative or project management experience in research or product development settings
  • Experience interacting with scientific stakeholders
  • Familiarity working in a Linux environment
  • Familiar with bioinformatics tools/software
  • Programming/scripting/database experience a plus (Python, bash, SQL, unix)
  • Experience with cloud computing, high performance computing clusters a plus
  • Wet bench biology experience a plus
  • Careful, detail-oriented working style
  • Initiative in suggesting and executing process improvements

 

The position reports to the Director, Product Development

Compensation:  Salary is industry-standard and is commensurate with experience.

To apply:  Please email cover letter and resume to [email protected]

Job ID: 2020-005

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